abstract：BACKGROUND:Growing evidences indicate that inhalational anaesthetics can enhance the growth and malignant potential of tumour cells and may affect tumour recurrence after surgery. Tumour stem cells play a vital role in tumour recurrence. This study investigates the effect of sevoflurane on glioma stem cells (GSCs) in v...

journal_title：British journal of anaesthesia

authors： Shi QY,Zhang SJ,Liu L,Chen QS,Yu LN,Zhang FJ,Yan M

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:We used an automated bispectral index (BIS)-guided dual-loop controller to determine propofol and remifentanil requirements during general anaesthesia in obese and lean surgical patients. METHODS:Obese patients, BMI>35 kg m(-2), and lean patients (<25 kg m(-2)) having laparoscopic procedures were prospectiv...

journal_title：British journal of anaesthesia

authors： Liu N,Lory C,Assenzo V,Cocard V,Chazot T,Le Guen M,Sessler DI,Journois D,Fischler M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The perioperative period may be associated with a marked neurohumoral stress response, significant fluid losses, and varied fluid replacement regimes. Acute changes in serum sodium concentration are therefore common, but predictors and outcomes of these changes have not been investigated in a large surgical ...

journal_title：British journal of anaesthesia

authors： Klinck J,McNeill L,Di Angelantonio E,Menon DK

更新日期：2015-04-01 00:00:00

abstract：:The determination of blood flow, i.e. cardiac output, is an integral part of haemodynamic monitoring. This is a review on noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. We present the underlying principles and validation data of the following technologies: thoracic elect...

journal_title：British journal of anaesthesia

authors： Saugel B,Cecconi M,Wagner JY,Reuter DA

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

journal_title：British journal of anaesthesia

authors： Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Current guidelines suggest a fasting time of 2 h for clear fluids, which is often exceeded in clinical practice, leading to discomfort, dehydration and stressful anaesthesia induction to patients, especially in the paediatric population. Shorter fluid fasting might be a strategy to improve patient comfort ...

journal_title：British journal of anaesthesia

authors： Schmidt AR,Buehler P,Seglias L,Stark T,Brotschi B,Renner T,Sabandal C,Klaghofer R,Weiss M,Schmitz A

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Early tracheostomy may decrease the duration of mechanical ventilation, sedation exposure, and intensive care stay, possibly resulting in improved clinical outcomes, but the evidence is conflicting. METHODS:Systematic review and meta-analysis of randomized trials in patients allocated to tracheostomy within...

journal_title：British journal of anaesthesia

authors： Szakmany T,Russell P,Wilkes AR,Hall JE

更新日期：2015-03-01 00:00:00

abstract：:The concept of rapid delivery of multiple blood products to the bedside of a massively haemorrhaging patient seems to be a logical approach to the management of the massively bleeding patient. However, controversy exists in the use of fixed blood component ratios. Assessing the extent of the coagulopathy through point...

journal_title：British journal of anaesthesia

authors： Waters JH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The effect of anaesthesia on postoperative outcome is unclear. Cardioprotective properties of volatile anaesthetics have been demonstrated experimentally and in haemodynamically stable patients undergoing coronary artery bypass grafting. Their effects in patients undergoing high-risk cardiac surgery have not...

journal_title：British journal of anaesthesia

authors： Landoni G,Guarracino F,Cariello C,Franco A,Baldassarri R,Borghi G,Covello RD,Gerli C,Crivellari M,Zangrillo A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery. We thus aimed to assess the absorption and safety of enterally administered clonidine in this setting. METHODS:Sixteen infants (median age 6.7 months) received a singl...

journal_title：British journal of anaesthesia

authors： Arenas-Lopez S,Mulla H,Manna S,Durward A,Murdoch IA,Tibby SM

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Low bispectral index values frequently reflect EEG suppression and have been associated with postoperative mortality. This study investigated whether intraoperative EEG suppression was an independent predictor of 90 day postoperative mortality and explored risk factors for EEG suppression. METHODS:This obse...

journal_title：British journal of anaesthesia

authors： Willingham M,Ben Abdallah A,Gradwohl S,Helsten D,Lin N,Villafranca A,Jacobsohn E,Avidan M,Kaiser H

更新日期：2014-12-01 00:00:00

abstract：:Cryoprecipitate, originally developed as a therapy for patients with antihaemophilic factor deficiency, or haemophilia A, has been in use for almost 50 yr. However, cryoprecipitate is no longer administered according to its original purpose, and is now most commonly used to replenish fibrinogen levels in patients with...

journal_title：British journal of anaesthesia

authors： Nascimento B,Goodnough LT,Levy JH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Miller laryngoscope blades are preferred for laryngoscopy in infants and children <2 yr of age. Despite their long history, the laryngeal view with the Miller blade size 1 has never been compared with that with the Macintosh (MAC) blade in children. This prospective, single-blinded, randomized study was desi...

journal_title：British journal of anaesthesia

authors： Passi Y,Sathyamoorthy M,Lerman J,Heard C,Marino M

更新日期：2014-11-01 00:00:00

abstract：:I.V. fluid therapy plays a fundamental role in the management of hospitalized patients. While the correct use of i.v. fluids can be lifesaving, recent literature demonstrates that fluid therapy is not without risks. Indeed, the use of certain types and volumes of fluid can increase the risk of harm, and even death, in...

journal_title：British journal of anaesthesia

authors： Hoste EA,Maitland K,Brudney CS,Mehta R,Vincent JL,Yates D,Kellum JA,Mythen MG,Shaw AD,ADQI XII Investigators Group.

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Isoflurane has been reported to induce caspase-3 activation, which may induce neurotoxicity and contribute to the pathogenesis of Alzheimer's disease. However, the underlying mechanism is largely unknown, especially whether or not isoflurane can induce ryanodine receptors (RyRs)-associated endoplasmic reticu...

journal_title：British journal of anaesthesia

authors： Wang H,Dong Y,Zhang J,Xu Z,Wang G,Swain CA,Zhang Y,Xie Z

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Cardiac output (CO) monitoring is helpful in the assessment of critically ill pregnant women, but invasive monitors are often unsuitable for use. We aimed to measure agreement between the non-invasive ultrasound cardiac output monitor (USCOM) and three-dimensional transthoracic echocardiography (3D-TTE) in p...

journal_title：British journal of anaesthesia

authors： McNamara H,Barclay P,Sharma V

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Assessments of labour pain focus on pain intensity, not on duration. We aimed to assess the importance labouring women apply to pain intensity and duration before labour and post-delivery. METHODS:Forty healthy women scheduled for labour induction were enrolled in this institutional review board-approved, p...

journal_title：British journal of anaesthesia

authors： Carvalho B,Hilton G,Wen L,Weiniger CF

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Tapentadol is an analgesic agent for treatment of acute and chronic pain that activates the µ-opioid receptor combined with inhibition of neuronal norepinephrine reuptake. Both mechanisms are implicated in activation of descending inhibitory pain pathways. In this study, we investigated the influence of tape...

journal_title：British journal of anaesthesia

authors： Niesters M,Proto PL,Aarts L,Sarton EY,Drewes AM,Dahan A

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:While volatile agents have been implicated in metastasis-enhancing effects on cancer cells, the effects of xenon are unknown. We investigated xenon- and sevoflurane-mediated effects on migration and expression of angiogenesis biomarkers in human breast adenocarcinoma cells. METHODS:MDA-MB-231 and MCF-7 cell...

journal_title：British journal of anaesthesia

authors： Ash SA,Valchev GI,Looney M,Ni Mhathuna A,Crowley PD,Gallagher HC,Buggy DJ

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The effect of anaesthetic drugs on long-term oncological outcomes after cancer surgery is an area of current interest. Dexamethasone is widely used in anaesthetic practice; however, its effect on long-term survival and cancer outcomes is not known. This study presents the results of a 5-yr follow-up of patie...

journal_title：British journal of anaesthesia

authors： Singh PP,Lemanu DP,Taylor MH,Hill AG

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Serum vascular endothelial growth factor-C (VEGF-C), transforming growth factor-β (TGF-β), and interleukin (IL)-6 promote angiogenesis and metastases in colon cancer. We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-β, and IL-6 and an incre...

journal_title：British journal of anaesthesia

authors： Xu YJ,Chen WK,Zhu Y,Wang SL,Miao CH

更新日期：2014-07-01 00:00:00

abstract：:We report a case of improved cardiopulmonary exercise (CPX) test outcomes measured 48 h after initial CPX testing and immediately after alterations were made to the settings of a dual chamber, dual sensing pacemaker with exercise detection. The changes allowed successful abdominal surgery to be completed. ...

journal_title：British journal of anaesthesia

authors： Bolsin S,Colson M,Ridley D,Ward C

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. We assessed the effect of transcutaneous electric acupoint...

journal_title：British journal of anaesthesia

authors： Wang H,Xie Y,Zhang Q,Xu N,Zhong H,Dong H,Liu L,Jiang T,Wang Q,Xiong L

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine whether assessment of stroke volume (SV) and measurement of exhaled end-tidal carbon dioxide [Formula: see text] during an end-expiratory occlusion (EEO) test can predict fluid responsiveness in the operating theatre. METHODS:Forty-two subjects monitored by oesop...

journal_title：British journal of anaesthesia

authors： Guinot PG,Godart J,de Broca B,Bernard E,Lorne E,Dupont H

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:This study focuses on a recently developed robotic nerve block system and its impact on learning regional anaesthesia skills. We compared success rates, learning curves, performance times, and inter-subject performance variability of robot-assisted vs manual ultrasound (US)-guided nerve block needle guidance...

journal_title：British journal of anaesthesia

authors： Morse J,Terrasini N,Wehbe M,Philippona C,Zaouter C,Cyr S,Hemmerling TM

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...

journal_title：British journal of anaesthesia

authors： Fletcher D,Martinez V

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Supraglottic airways (SGAs) have an established role in airway management of difficult airways in both adults and children. However, there are limited data regarding the use of SGAs for primary airway management in children. The aim of this study is to assess the success rates and adverse events related to t...

journal_title：British journal of anaesthesia

authors： Jagannathan N,Sequera-Ramos L,Sohn L,Wallis B,Shertzer A,Schaldenbrand K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The use of lipid emulsions to reduce cardiac toxicity of local anaesthetics (LAs) has shown success in experimental studies and some clinical cases, and thus has been implemented in clinical practice. However, lipid treatment is usually given after the occurrence of neurological or cardiovascular symptoms of...

journal_title：British journal of anaesthesia

authors： Aumeier C,Kasdorf B,Gruber M,Busse H,Wiese CH,Zink W,Graf BM,Zausig YA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the efficacy of palonosetron, the latest 5-HT3 receptor antagonist, for the prevention of postoperative nausea and vomiting (PONV) during the first 72 h after operation. METHODS:In this randomized, double-blinded, placebo-controlled study, 204 healthy inpatients who wer...

journal_title：British journal of anaesthesia

authors： Chun HR,Jeon IS,Park SY,Lee SJ,Kang SH,Kim SI

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:In critically ill children, monitoring of cardiac output (CO) is essential to guide haemodynamic management and facilitate cardiovascular therapy. The ultrasound dilution technique (UDT), a novel minimally invasive indicator method, was recently introduced to determine CO. We validated UDT against the 'gold ...

journal_title：British journal of anaesthesia

authors： Boehne M,Baustert M,Paetzel V,Köditz H,Schoof S,Happel CM,Bertram H

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Signalling of several G-protein-coupled receptors of the Gq/11 family is time-dependently inhibited by local anaesthetics (LAs). Since LA-induced modulation of muscarinic m1 and m3 receptor function may explain their beneficial effects in clinical practice, such as decreased postoperative cognitive dysfuncti...

journal_title：British journal of anaesthesia

authors： Picardi S,Stevens MF,Hahnenkamp K,Durieux ME,Lirk P,Hollmann MW

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...

journal_title：British journal of anaesthesia

authors： Bergström A,Staalsø JM,Romner B,Olsen NV

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Treprostinil sodium improves haemodynamics and symptoms in pulmonary arterial hypertension (PAH) patients, but its subcutaneous (s.c.) administration can produce severe local site pain, and lead to discontinuation of vital treatment. Treprostinil is a prostacyclin analogue which stimulates prostacyclin recep...

journal_title：British journal of anaesthesia

authors： Libri V,Gibbs JS,Pinato DJ,Iddamalgoda T,Khengar RH,Gin-Sing W,Huson L,Anand P

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Owing to complexities of measuring dead space, ventilatory failure is difficult to quantify in critical care. A simple, novel index called ventilatory ratio (VR) can quantify ventilatory efficiency at the bedside. The study objectives were to evaluate physiological properties of VR and examine its clinical a...

journal_title：British journal of anaesthesia

authors： Sinha P,Singh S,Hardman JG,Bersten AD,Soni N,Australia and New Zealand Intensive Care Society Clinical Trials Group.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The properties of methadone suggest a potential advantage for epidural over i.v. administration for pain relief, but little supportive evidence exists. METHODS:To investigate the pharmacokinetic and the pharmacodynamic properties of epidural and i.v. methadone, four doses of methadone (0.1, 0.25, 0.5, and 0...

journal_title：British journal of anaesthesia

authors： Haroutiunian S,Kagan L,Yifrach-Damari I,Davidson E,Ratz Y,Hoffman A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Blood flow patterns are important modifiers of platelet interactions with plasma coagulation factors. However, it is not feasible to evaluate rheological effects of haemodilution on coagulation using conventional coagulation testing. METHODS:We evaluated thrombus formation with a microchip-based flow-chambe...

journal_title：British journal of anaesthesia

authors： Ogawa S,Ohnishi T,Hosokawa K,Szlam F,Chen EP,Tanaka KA

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The ultrasound cardiac output monitor (USCOM) is a continuous wave Doppler system designed to measure cardiac output (CO) non-invasively and intermittently either from the pulmonary or from the aortic valve. USCOM scan quality is critical to obtaining reliable data and during anaesthesia it is said to deteri...

journal_title：British journal of anaesthesia

authors： Huang L,Critchley LA

更新日期：2013-12-01 00:00:00

abstract：:Blood transfusion saves many lives but carries significant risk of injury. Currently, red blood cell (RBC) concentrates can be stored up to 42 days. Concerns have recently been raised about the safety and efficacy of transfusing stored RBCs. Refrigerated storage results in a 'storage lesion' that is reflected by metab...

journal_title：British journal of anaesthesia

authors： Cohen B,Matot I

更新日期：2013-12-01 00:00:00

abstract：:The face-grafting techniques are innovative and highly complex, requiring well-defined organization of all the teams involved. Subsequent to the first report in France in 2005, there have been 17 facial allograft transplantations performed worldwide. We describe anaesthesia and postoperative management, and the proble...

journal_title：British journal of anaesthesia

authors： Sedaghati-nia A,Gilton A,Liger C,Binhas M,Cook F,Ait-Mammar B,Scherrer E,Hivelin M,Lantieri L,Marty J,Plaud B

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The analgesia/nociception index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the analgesia/nociception balance during general anaesthesia. The aim of this study was to evaluate the ANI in the assessment of immediate postoperative pain in adult patients undergoing general...

journal_title：British journal of anaesthesia

authors： Boselli E,Daniela-Ionescu M,Bégou G,Bouvet L,Dabouz R,Magnin C,Allaouchiche B

更新日期：2013-09-01 00:00:00